diff --git a/homeassistant/components/velbus/config_flow.py b/homeassistant/components/velbus/config_flow.py
index 3a057b482df..189dc029ded 100644
--- a/homeassistant/components/velbus/config_flow.py
+++ b/homeassistant/components/velbus/config_flow.py
@@ -8,6 +8,7 @@ from velbusaio.exceptions import VelbusConnectionFailed
 import voluptuous as vol
 
 from homeassistant import config_entries
+from homeassistant.components import usb
 from homeassistant.const import CONF_NAME, CONF_PORT
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.data_entry_flow import FlowResult
@@ -32,6 +33,8 @@ class VelbusConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
     def __init__(self) -> None:
         """Initialize the velbus config flow."""
         self._errors: dict[str, str] = {}
+        self._device: str = ""
+        self._title: str = ""
 
     def _create_device(self, name: str, prt: str) -> FlowResult:
         """Create an entry async."""
@@ -50,9 +53,7 @@ class VelbusConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
 
     def _prt_in_configuration_exists(self, prt: str) -> bool:
         """Return True if port exists in configuration."""
-        if prt in velbus_entries(self.hass):
-            return True
-        return False
+        return prt in velbus_entries(self.hass)
 
     async def async_step_user(
         self, user_input: dict[str, Any] | None = None
@@ -82,3 +83,37 @@ class VelbusConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
             ),
             errors=self._errors,
         )
+
+    async def async_step_usb(self, discovery_info: usb.UsbServiceInfo) -> FlowResult:
+        """Handle USB Discovery."""
+        await self.async_set_unique_id(
+            f"{discovery_info.vid}:{discovery_info.pid}_{discovery_info.serial_number}_{discovery_info.manufacturer}_{discovery_info.description}"
+        )
+        dev_path = await self.hass.async_add_executor_job(
+            usb.get_serial_by_id, discovery_info.device
+        )
+        # check if this device is not already configured
+        if self._prt_in_configuration_exists(dev_path):
+            return self.async_abort(reason="already_configured")
+        # check if we can make a valid velbus connection
+        if not await self._test_connection(dev_path):
+            return self.async_abort(reason="cannot_connect")
+        # store the data for the config step
+        self._device = dev_path
+        self._title = "Velbus USB"
+        # call the config step
+        self._set_confirm_only()
+        return await self.async_step_discovery_confirm()
+
+    async def async_step_discovery_confirm(
+        self, user_input: dict[str, Any] | None = None
+    ) -> FlowResult:
+        """Handle Discovery confirmation."""
+        if user_input is not None:
+            return self._create_device(self._title, self._device)
+
+        return self.async_show_form(
+            step_id="discovery_confirm",
+            description_placeholders={CONF_NAME: self._title},
+            data_schema=vol.Schema({}),
+        )
diff --git a/homeassistant/components/velbus/manifest.json b/homeassistant/components/velbus/manifest.json
index 63d74536378..f52ba0fd99d 100644
--- a/homeassistant/components/velbus/manifest.json
+++ b/homeassistant/components/velbus/manifest.json
@@ -5,5 +5,24 @@
   "requirements": ["velbus-aio==2021.11.7"],
   "config_flow": true,
   "codeowners": ["@Cereal2nd", "@brefra"],
-  "iot_class": "local_push"
+  "dependencies": ["usb"],
+  "iot_class": "local_push",
+  "usb": [
+    {
+    "vid": "10CF",
+    "pid": "0B1B"
+    },
+    {
+    "vid": "10CF",
+    "pid": "0516"
+    },
+    {
+    "vid": "10CF",
+    "pid": "0517"
+    },
+    {
+    "vid": "10CF",
+    "pid": "0518"
+    }
+  ]
 }
diff --git a/homeassistant/generated/usb.py b/homeassistant/generated/usb.py
index d9d9da5aff0..1ba9b235f85 100644
--- a/homeassistant/generated/usb.py
+++ b/homeassistant/generated/usb.py
@@ -11,6 +11,26 @@ USB = [
         "vid": "0572",
         "pid": "1340"
     },
+    {
+        "domain": "velbus",
+        "vid": "10CF",
+        "pid": "0B1B"
+    },
+    {
+        "domain": "velbus",
+        "vid": "10CF",
+        "pid": "0516"
+    },
+    {
+        "domain": "velbus",
+        "vid": "10CF",
+        "pid": "0517"
+    },
+    {
+        "domain": "velbus",
+        "vid": "10CF",
+        "pid": "0518"
+    },
     {
         "domain": "zha",
         "vid": "10C4",
diff --git a/tests/components/velbus/test_config_flow.py b/tests/components/velbus/test_config_flow.py
index 01a40af1751..960eedcbd01 100644
--- a/tests/components/velbus/test_config_flow.py
+++ b/tests/components/velbus/test_config_flow.py
@@ -1,16 +1,41 @@
 """Tests for the Velbus config flow."""
-from unittest.mock import AsyncMock, patch
+from unittest.mock import AsyncMock, MagicMock, patch
 
 import pytest
+import serial.tools.list_ports
 from velbusaio.exceptions import VelbusConnectionFailed
 
 from homeassistant import data_entry_flow
+from homeassistant.components import usb
 from homeassistant.components.velbus import config_flow
-from homeassistant.const import CONF_NAME, CONF_PORT
+from homeassistant.components.velbus.const import DOMAIN
+from homeassistant.config_entries import SOURCE_USB
+from homeassistant.const import CONF_NAME, CONF_PORT, CONF_SOURCE
 from homeassistant.core import HomeAssistant
 
 from .const import PORT_SERIAL, PORT_TCP
 
+from tests.common import MockConfigEntry
+
+DISCOVERY_INFO = usb.UsbServiceInfo(
+    device=PORT_SERIAL,
+    pid="10CF",
+    vid="0B1B",
+    serial_number="1234",
+    description="Velbus VMB1USB",
+    manufacturer="Velleman",
+)
+
+
+def com_port():
+    """Mock of a serial port."""
+    port = serial.tools.list_ports_common.ListPortInfo(PORT_SERIAL)
+    port.serial_number = "1234"
+    port.manufacturer = "Virtual serial port"
+    port.device = PORT_SERIAL
+    port.description = "Some serial port"
+    return port
+
 
 @pytest.fixture(autouse=True)
 def override_async_setup_entry() -> AsyncMock:
@@ -85,3 +110,49 @@ async def test_abort_if_already_setup(hass: HomeAssistant):
     result = await flow.async_step_user({CONF_PORT: PORT_TCP, CONF_NAME: "velbus test"})
     assert result["type"] == data_entry_flow.RESULT_TYPE_FORM
     assert result["errors"] == {"port": "already_configured"}
+
+
+@pytest.mark.usefixtures("controller")
+@patch("serial.tools.list_ports.comports", MagicMock(return_value=[com_port()]))
+async def test_flow_usb(hass: HomeAssistant):
+    """Test usb discovery flow."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_USB},
+        data=DISCOVERY_INFO,
+    )
+    assert result["type"] == data_entry_flow.RESULT_TYPE_FORM
+    assert result["step_id"] == "discovery_confirm"
+
+    result = await hass.config_entries.flow.async_configure(
+        result["flow_id"],
+        user_input={},
+    )
+    assert result["type"] == data_entry_flow.RESULT_TYPE_CREATE_ENTRY
+
+    # test an already configured discovery
+    entry = MockConfigEntry(
+        domain=DOMAIN,
+        data={CONF_PORT: PORT_SERIAL},
+    )
+    entry.add_to_hass(hass)
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_USB},
+        data=DISCOVERY_INFO,
+    )
+    assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
+    assert result["reason"] == "already_configured"
+
+
+@pytest.mark.usefixtures("controller_connection_failed")
+@patch("serial.tools.list_ports.comports", MagicMock(return_value=[com_port()]))
+async def test_flow_usb_failed(hass: HomeAssistant):
+    """Test usb discovery flow with a failed velbus test."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_USB},
+        data=DISCOVERY_INFO,
+    )
+    assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
+    assert result["reason"] == "cannot_connect"