diff --git a/homeassistant/components/reolink/host.py b/homeassistant/components/reolink/host.py
index 9bcafb8f00d..feeff9312c7 100644
--- a/homeassistant/components/reolink/host.py
+++ b/homeassistant/components/reolink/host.py
@@ -231,6 +231,7 @@ class ReolinkHost:
                     "network_link": "https://my.home-assistant.io/redirect/network/",
                 },
             )
+
             if self._base_url.startswith("https"):
                 ir.async_create_issue(
                     self._hass,
@@ -246,9 +247,28 @@ class ReolinkHost:
                 )
             else:
                 ir.async_delete_issue(self._hass, DOMAIN, "https_webhook")
+
+            if self._hass.config.api is not None and self._hass.config.api.use_ssl:
+                ir.async_create_issue(
+                    self._hass,
+                    DOMAIN,
+                    "ssl",
+                    is_fixable=False,
+                    severity=ir.IssueSeverity.WARNING,
+                    translation_key="ssl",
+                    translation_placeholders={
+                        "ssl_link": "https://www.home-assistant.io/integrations/http/#ssl_certificate",
+                        "base_url": self._base_url,
+                        "network_link": "https://my.home-assistant.io/redirect/network/",
+                        "nginx_link": "https://github.com/home-assistant/addons/tree/master/nginx_proxy",
+                    },
+                )
+            else:
+                ir.async_delete_issue(self._hass, DOMAIN, "ssl")
         else:
             ir.async_delete_issue(self._hass, DOMAIN, "webhook_url")
             ir.async_delete_issue(self._hass, DOMAIN, "https_webhook")
+            ir.async_delete_issue(self._hass, DOMAIN, "ssl")
 
         # If no ONVIF push or long polling state is received, start fast polling
         await self._async_poll_all_motion()
diff --git a/homeassistant/components/reolink/strings.json b/homeassistant/components/reolink/strings.json
index 2389c433b20..806f2498094 100644
--- a/homeassistant/components/reolink/strings.json
+++ b/homeassistant/components/reolink/strings.json
@@ -44,6 +44,10 @@
       "title": "Reolink webhook URL uses HTTPS (SSL)",
       "description": "Reolink products can not push motion events to an HTTPS address (SSL), please configure a (local) HTTP address under \"Home Assistant URL\" in the [network settings]({network_link}). The current (local) address is: `{base_url}`, a valid address could, for example, be `http://192.168.1.10:8123` where `192.168.1.10` is the IP of the Home Assistant device"
     },
+    "ssl": {
+      "title": "Reolink incompatible with global SSL certificate",
+      "description": "Global SSL certificate configured in the [configuration.yaml under http]({ssl_link}) while a local HTTP address `{base_url}` is configured under \"Home Assistant URL\" in the [network settings]({network_link}). Therefore the Reolink device can not reach Home Assistant to push its motion/AI events. Please make sure the local HTTP adress is not covered by the SSL certificate, by for instance using [NGINX add-on]({nginx_link}) instead of a globally enforced SSL certificate."
+    },
     "webhook_url": {
       "title": "Reolink webhook URL unreachable",
       "description": "Did not receive initial ONVIF state from {name}. Most likely, the Reolink camera can not reach the current (local) Home Assistant URL `{base_url}`, please configure a (local) HTTP address under \"Home Assistant URL\" in the [network settings]({network_link}) that points to Home Assistant. For example `http://192.168.1.10:8123` where `192.168.1.10` is the IP of the Home Assistant device. Also, make sure the Reolink camera can reach that URL. Using fast motion/AI state polling until the first ONVIF push is received."
diff --git a/tests/components/reolink/test_init.py b/tests/components/reolink/test_init.py
index f5f581760c1..8558ff0e8a2 100644
--- a/tests/components/reolink/test_init.py
+++ b/tests/components/reolink/test_init.py
@@ -10,6 +10,7 @@ from homeassistant.config import async_process_ha_core_config
 from homeassistant.config_entries import ConfigEntryState
 from homeassistant.core import HomeAssistant
 from homeassistant.helpers import issue_registry as ir
+from homeassistant.setup import async_setup_component
 
 from tests.common import MockConfigEntry
 
@@ -106,6 +107,7 @@ async def test_no_repair_issue(
     assert (const.DOMAIN, "webhook_url") not in issue_registry.issues
     assert (const.DOMAIN, "enable_port") not in issue_registry.issues
     assert (const.DOMAIN, "firmware_update") not in issue_registry.issues
+    assert (const.DOMAIN, "ssl") not in issue_registry.issues
 
 
 async def test_https_repair_issue(
@@ -130,6 +132,31 @@ async def test_https_repair_issue(
     assert (const.DOMAIN, "https_webhook") in issue_registry.issues
 
 
+async def test_ssl_repair_issue(
+    hass: HomeAssistant, config_entry: MockConfigEntry, reolink_ONVIF_wait: MagicMock
+) -> None:
+    """Test repairs issue is raised when global ssl certificate is used."""
+    assert await async_setup_component(hass, "webhook", {})
+    hass.config.api.use_ssl = True
+
+    await async_process_ha_core_config(
+        hass, {"country": "GB", "internal_url": "http://test_homeassistant_address"}
+    )
+
+    with patch(
+        "homeassistant.components.reolink.host.FIRST_ONVIF_TIMEOUT", new=0
+    ), patch(
+        "homeassistant.components.reolink.host.FIRST_ONVIF_LONG_POLL_TIMEOUT", new=0
+    ), patch(
+        "homeassistant.components.reolink.host.ReolinkHost._async_long_polling",
+    ):
+        assert await hass.config_entries.async_setup(config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    issue_registry = ir.async_get(hass)
+    assert (const.DOMAIN, "ssl") in issue_registry.issues
+
+
 @pytest.mark.parametrize("protocol", ["rtsp", "rtmp"])
 async def test_port_repair_issue(
     hass: HomeAssistant,