diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 9c9354c584b..ec3ac5de9b3 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -50,8 +50,8 @@ httplib2>=0.19.0
 # gRPC is an implicit dependency that we want to make explicit so we manage
 # upgrades intentionally. It is a large package to build from source and we
 # want to ensure we have wheels built.
-grpcio==1.45.0
-grpcio-status==1.45.0
+grpcio==1.46.1
+grpcio-status==1.46.1
 
 # libcst >=0.4.0 requires a newer Rust than we currently have available,
 # thus our wheels builds fail. This pins it to the last working version,
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index be94fdac22b..369045e5124 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -66,8 +66,8 @@ httplib2>=0.19.0
 # gRPC is an implicit dependency that we want to make explicit so we manage
 # upgrades intentionally. It is a large package to build from source and we
 # want to ensure we have wheels built.
-grpcio==1.45.0
-grpcio-status==1.45.0
+grpcio==1.46.1
+grpcio-status==1.46.1
 
 # libcst >=0.4.0 requires a newer Rust than we currently have available,
 # thus our wheels builds fail. This pins it to the last working version,