diff --git a/homeassistant/helpers/device_registry.py b/homeassistant/helpers/device_registry.py
index 5395218b48e..65df557b582 100644
--- a/homeassistant/helpers/device_registry.py
+++ b/homeassistant/helpers/device_registry.py
@@ -501,6 +501,9 @@ class DeviceRegistry:
                 orphaned_timestamp=None,
             )
         )
+        for other_device in list(self.devices.values()):
+            if other_device.via_device_id == device_id:
+                self._async_update_device(other_device.id, via_device_id=None)
         self.hass.bus.async_fire(
             EVENT_DEVICE_REGISTRY_UPDATED, {"action": "remove", "device_id": device_id}
         )
diff --git a/tests/helpers/test_device_registry.py b/tests/helpers/test_device_registry.py
index 8c311d44588..939387f411a 100644
--- a/tests/helpers/test_device_registry.py
+++ b/tests/helpers/test_device_registry.py
@@ -420,7 +420,7 @@ async def test_deleted_device_removing_area_id(registry):
 
 
 async def test_specifying_via_device_create(registry):
-    """Test specifying a via_device and updating."""
+    """Test specifying a via_device and removal of the hub device."""
     via = registry.async_get_or_create(
         config_entry_id="123",
         connections={(device_registry.CONNECTION_NETWORK_MAC, "12:34:56:AB:CD:EF")},
@@ -440,6 +440,10 @@ async def test_specifying_via_device_create(registry):
 
     assert light.via_device_id == via.id
 
+    registry.async_remove_device(via.id)
+    light = registry.async_get_device({("hue", "456")})
+    assert light.via_device_id is None
+
 
 async def test_specifying_via_device_update(registry):
     """Test specifying a via_device and updating."""