diff --git a/homeassistant/components/onewire/sensor.py b/homeassistant/components/onewire/sensor.py
index 89a01496b1f..a21a093e0a1 100644
--- a/homeassistant/components/onewire/sensor.py
+++ b/homeassistant/components/onewire/sensor.py
@@ -9,6 +9,8 @@ import os
 from types import MappingProxyType
 from typing import Any
 
+from pyownet import protocol
+
 from homeassistant.components.sensor import (
     SensorDeviceClass,
     SensorEntity,
@@ -419,6 +421,17 @@ def get_entities(
                 override_key or description.key,
             )
             name = f"{device_id} {description.name}"
+            if family == "12":
+                # We need to check if there is TAI8570 plugged in
+                try:
+                    onewire_hub.owproxy.read(device_file)
+                except protocol.OwnetError as err:
+                    _LOGGER.debug(
+                        "Ignoring unreachable sensor %s",
+                        device_file,
+                        exc_info=err,
+                    )
+                    continue
             entities.append(
                 OneWireSensor(
                     description=description,
diff --git a/tests/components/onewire/__init__.py b/tests/components/onewire/__init__.py
index c916c777248..96c5dd8ca13 100644
--- a/tests/components/onewire/__init__.py
+++ b/tests/components/onewire/__init__.py
@@ -178,5 +178,9 @@ def _setup_owproxy_mock_device_reads(
 
     # Setup sub-device reads
     device_sensors = mock_device.get(platform, [])
+    if platform is Platform.SENSOR and device_id.startswith("12"):
+        # We need to check if there is TAI8570 plugged in
+        for expected_sensor in device_sensors:
+            sub_read_side_effect.append(expected_sensor[ATTR_INJECT_READS])
     for expected_sensor in device_sensors:
         sub_read_side_effect.append(expected_sensor[ATTR_INJECT_READS])
diff --git a/tests/components/onewire/test_sensor.py b/tests/components/onewire/test_sensor.py
index 123ccf7a506..08b44844710 100644
--- a/tests/components/onewire/test_sensor.py
+++ b/tests/components/onewire/test_sensor.py
@@ -1,12 +1,14 @@
 """Tests for 1-Wire sensors."""
 from collections.abc import Generator
+from copy import deepcopy
 import logging
-from unittest.mock import MagicMock, patch
+from unittest.mock import MagicMock, _patch_dict, patch
 
+from pyownet.protocol import OwnetError
 import pytest
 
 from homeassistant.config_entries import ConfigEntry
-from homeassistant.const import Platform
+from homeassistant.const import ATTR_ENTITY_ID, Platform
 from homeassistant.core import HomeAssistant
 from homeassistant.helpers.config_validation import ensure_list
 
@@ -16,7 +18,12 @@ from . import (
     check_entities,
     setup_owproxy_mock_devices,
 )
-from .const import ATTR_DEVICE_INFO, ATTR_UNKNOWN_DEVICE, MOCK_OWPROXY_DEVICES
+from .const import (
+    ATTR_DEVICE_INFO,
+    ATTR_INJECT_READS,
+    ATTR_UNKNOWN_DEVICE,
+    MOCK_OWPROXY_DEVICES,
+)
 
 from tests.common import mock_device_registry, mock_registry
 
@@ -68,3 +75,31 @@ async def test_sensors(
     await hass.async_block_till_done()
 
     check_entities(hass, entity_registry, expected_entities)
+
+
+@pytest.mark.parametrize("device_id", ["12.111111111111"])
+async def test_tai8570_sensors(
+    hass: HomeAssistant, config_entry: ConfigEntry, owproxy: MagicMock, device_id: str
+) -> None:
+    """The DS2602 is often used without TAI8570.
+
+    The sensors should be ignored.
+    """
+    entity_registry = mock_registry(hass)
+
+    mock_devices = deepcopy(MOCK_OWPROXY_DEVICES)
+    mock_device = mock_devices[device_id]
+    mock_device[ATTR_INJECT_READS].append(OwnetError)
+    mock_device[ATTR_INJECT_READS].append(OwnetError)
+
+    with _patch_dict(MOCK_OWPROXY_DEVICES, mock_devices):
+        setup_owproxy_mock_devices(owproxy, Platform.SENSOR, [device_id])
+
+    await hass.config_entries.async_setup(config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    expected_entities = mock_device[Platform.SENSOR]
+    for expected_entity in expected_entities:
+        entity_id = expected_entity[ATTR_ENTITY_ID]
+        registry_entry = entity_registry.entities.get(entity_id)
+        assert registry_entry is None