diff --git a/homeassistant/components/daikin/config_flow.py b/homeassistant/components/daikin/config_flow.py
index 467d91328b5..7576aa8a91b 100644
--- a/homeassistant/components/daikin/config_flow.py
+++ b/homeassistant/components/daikin/config_flow.py
@@ -130,6 +130,13 @@ class FlowHandler(config_entries.ConfigFlow):
         """Prepare configuration for a discovered Daikin device."""
         _LOGGER.debug("Zeroconf user_input: %s", discovery_info)
         devices = Discovery().poll(ip=discovery_info[CONF_HOST])
+        if not devices:
+            _LOGGER.debug(
+                "Could not find MAC-address for %s,"
+                " make sure the required UDP ports are open (see integration documentation).",
+                discovery_info[CONF_HOST],
+            )
+            return self.async_abort(reason="cannot_connect")
         await self.async_set_unique_id(next(iter(devices))[KEY_MAC])
         self._abort_if_unique_id_configured()
         self.host = discovery_info[CONF_HOST]
diff --git a/homeassistant/components/daikin/strings.json b/homeassistant/components/daikin/strings.json
index c60163577a6..a8ebe0911b6 100644
--- a/homeassistant/components/daikin/strings.json
+++ b/homeassistant/components/daikin/strings.json
@@ -12,7 +12,8 @@
       }
     },
     "abort": {
-      "already_configured": "[%key:common::config_flow::abort::already_configured_device%]"
+      "already_configured": "[%key:common::config_flow::abort::already_configured_device%]",
+      "cannot_connect": "[%key:common::config_flow::error::cannot_connect%]"
     },
     "error": {
       "device_fail": "[%key:common::config_flow::error::unknown%]",