diff --git a/homeassistant/components/onvif/camera.py b/homeassistant/components/onvif/camera.py
index ce241f779b1..cb518d6c5ee 100644
--- a/homeassistant/components/onvif/camera.py
+++ b/homeassistant/components/onvif/camera.py
@@ -505,4 +505,6 @@ class ONVIFHassCamera(Camera):
     @property
     def unique_id(self) -> Optional[str]:
         """Return a unique ID."""
+        if self._profile_index:
+            return f"{self._mac}_{self._profile_index}"
         return self._mac