diff --git a/homeassistant/components/plugwise/coordinator.py b/homeassistant/components/plugwise/coordinator.py
index bc12ef4443b..8958ecae930 100644
--- a/homeassistant/components/plugwise/coordinator.py
+++ b/homeassistant/components/plugwise/coordinator.py
@@ -16,11 +16,12 @@ from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import CONF_HOST, CONF_PASSWORD, CONF_PORT, CONF_USERNAME
 from homeassistant.core import HomeAssistant
 from homeassistant.exceptions import ConfigEntryError
+from homeassistant.helpers import device_registry as dr
 from homeassistant.helpers.aiohttp_client import async_get_clientsession
 from homeassistant.helpers.debounce import Debouncer
 from homeassistant.helpers.update_coordinator import DataUpdateCoordinator, UpdateFailed
 
-from .const import DEFAULT_PORT, DEFAULT_USERNAME, DOMAIN, LOGGER
+from .const import DEFAULT_PORT, DEFAULT_USERNAME, DOMAIN, GATEWAY_ID, LOGGER
 
 
 class PlugwiseDataUpdateCoordinator(DataUpdateCoordinator[PlugwiseData]):
@@ -83,7 +84,46 @@ class PlugwiseDataUpdateCoordinator(DataUpdateCoordinator[PlugwiseData]):
         except UnsupportedDeviceError as err:
             raise ConfigEntryError("Device with unsupported firmware") from err
         else:
-            self.new_devices = set(data.devices) - self._current_devices
-            self._current_devices = set(data.devices)
+            self._async_add_remove_devices(data, self.config_entry)
 
         return data
+
+    def _async_add_remove_devices(self, data: PlugwiseData, entry: ConfigEntry) -> None:
+        """Add new Plugwise devices, remove non-existing devices."""
+        # Check for new or removed devices
+        self.new_devices = set(data.devices) - self._current_devices
+        removed_devices = self._current_devices - set(data.devices)
+        self._current_devices = set(data.devices)
+
+        if removed_devices:
+            self._async_remove_devices(data, entry)
+
+    def _async_remove_devices(self, data: PlugwiseData, entry: ConfigEntry) -> None:
+        """Clean registries when removed devices found."""
+        device_reg = dr.async_get(self.hass)
+        device_list = dr.async_entries_for_config_entry(
+            device_reg, self.config_entry.entry_id
+        )
+        # via_device cannot be None, this will result in the deletion
+        # of other Plugwise Gateways when present!
+        via_device: str = ""
+        for device_entry in device_list:
+            if device_entry.identifiers:
+                item = list(list(device_entry.identifiers)[0])
+                if item[0] == DOMAIN:
+                    # First find the Plugwise via_device, this is always the first device
+                    if item[1] == data.gateway[GATEWAY_ID]:
+                        via_device = device_entry.id
+                    elif (  # then remove the connected orphaned device(s)
+                        device_entry.via_device_id == via_device
+                        and item[1] not in data.devices
+                    ):
+                        device_reg.async_update_device(
+                            device_entry.id, remove_config_entry_id=entry.entry_id
+                        )
+                        LOGGER.debug(
+                            "Removed %s device %s %s from device_registry",
+                            DOMAIN,
+                            device_entry.model,
+                            item[1],
+                        )
diff --git a/tests/components/plugwise/test_init.py b/tests/components/plugwise/test_init.py
index d3f23a18285..26aedf864dc 100644
--- a/tests/components/plugwise/test_init.py
+++ b/tests/components/plugwise/test_init.py
@@ -39,7 +39,7 @@ TOM = {
         "hardware": "1",
         "location": "f871b8c4d63549319221e294e4f88074",
         "model": "Tom/Floor",
-        "name": "Tom Badkamer",
+        "name": "Tom Zolder",
         "sensors": {
             "battery": 99,
             "temperature": 18.6,
@@ -258,3 +258,30 @@ async def test_update_device(
         for device_entry in list(device_registry.devices.values()):
             item_list.extend(x[1] for x in device_entry.identifiers)
         assert "01234567890abcdefghijklmnopqrstu" in item_list
+
+    # Remove the existing Tom/Floor
+    data.devices.pop("1772a4ea304041adb83f357b751341ff")
+    with patch(HA_PLUGWISE_SMILE_ASYNC_UPDATE, return_value=data):
+        async_fire_time_changed(hass, utcnow + timedelta(minutes=1))
+        await hass.async_block_till_done()
+
+        assert (
+            len(
+                er.async_entries_for_config_entry(
+                    entity_registry, mock_config_entry.entry_id
+                )
+            )
+            == 29
+        )
+        assert (
+            len(
+                dr.async_entries_for_config_entry(
+                    device_registry, mock_config_entry.entry_id
+                )
+            )
+            == 6
+        )
+        item_list: list[str] = []
+        for device_entry in list(device_registry.devices.values()):
+            item_list.extend(x[1] for x in device_entry.identifiers)
+        assert "1772a4ea304041adb83f357b751341ff" not in item_list