diff --git a/homeassistant/components/zeroconf/__init__.py b/homeassistant/components/zeroconf/__init__.py
index 17cfb9d05de..4afb0a3c24d 100644
--- a/homeassistant/components/zeroconf/__init__.py
+++ b/homeassistant/components/zeroconf/__init__.py
@@ -5,9 +5,10 @@ import asyncio
 from collections.abc import Coroutine
 from contextlib import suppress
 import fnmatch
-from ipaddress import IPv6Address, ip_address
+from ipaddress import IPv4Address, IPv6Address, ip_address
 import logging
 import socket
+import sys
 from typing import Any, TypedDict, cast
 
 import voluptuous as vol
@@ -131,18 +132,31 @@ async def _async_get_instance(hass: HomeAssistant, **zcargs: Any) -> HaAsyncZero
     return aio_zc
 
 
+@callback
+def _async_zc_has_functional_dual_stack() -> bool:
+    """Return true for platforms that not support IP_ADD_MEMBERSHIP on an AF_INET6 socket.
+
+    Zeroconf only supports a single listen socket at this time.
+    """
+    return not sys.platform.startswith("freebsd") and not sys.platform.startswith(
+        "darwin"
+    )
+
+
 async def async_setup(hass: HomeAssistant, config: ConfigType) -> bool:
     """Set up Zeroconf and make Home Assistant discoverable."""
-    zc_args: dict = {}
+    zc_args: dict = {"ip_version": IPVersion.V4Only}
 
     adapters = await network.async_get_adapters(hass)
 
-    ipv6 = True
-    if not any(adapter["enabled"] and adapter["ipv6"] for adapter in adapters):
-        ipv6 = False
-        zc_args["ip_version"] = IPVersion.V4Only
-    else:
-        zc_args["ip_version"] = IPVersion.All
+    ipv6 = False
+    if _async_zc_has_functional_dual_stack():
+        if any(adapter["enabled"] and adapter["ipv6"] for adapter in adapters):
+            ipv6 = True
+            zc_args["ip_version"] = IPVersion.All
+    elif not any(adapter["enabled"] and adapter["ipv4"] for adapter in adapters):
+        zc_args["ip_version"] = IPVersion.V6Only
+        ipv6 = True
 
     if not ipv6 and network.async_only_default_interface_enabled(adapters):
         zc_args["interfaces"] = InterfaceChoice.Default
@@ -152,6 +166,14 @@ async def async_setup(hass: HomeAssistant, config: ConfigType) -> bool:
             for source_ip in await network.async_get_enabled_source_ips(hass)
             if not source_ip.is_loopback
             and not (isinstance(source_ip, IPv6Address) and source_ip.is_global)
+            and not (
+                isinstance(source_ip, IPv6Address)
+                and zc_args["ip_version"] == IPVersion.V4Only
+            )
+            and not (
+                isinstance(source_ip, IPv4Address)
+                and zc_args["ip_version"] == IPVersion.V6Only
+            )
         ]
 
     aio_zc = await _async_get_instance(hass, **zc_args)
diff --git a/tests/components/zeroconf/test_init.py b/tests/components/zeroconf/test_init.py
index b8ce28b6259..0d3c5fc7792 100644
--- a/tests/components/zeroconf/test_init.py
+++ b/tests/components/zeroconf/test_init.py
@@ -779,11 +779,13 @@ _ADAPTERS_WITH_MANUAL_CONFIG = [
 ]
 
 
-async def test_async_detect_interfaces_setting_empty_route(hass, mock_async_zeroconf):
-    """Test without default interface config and the route returns nothing."""
-    with patch("homeassistant.components.zeroconf.HaZeroconf") as mock_zc, patch.object(
-        hass.config_entries.flow, "async_init"
-    ), patch.object(
+async def test_async_detect_interfaces_setting_empty_route_linux(
+    hass, mock_async_zeroconf
+):
+    """Test without default interface config and the route returns nothing on linux."""
+    with patch("homeassistant.components.zeroconf.sys.platform", "linux"), patch(
+        "homeassistant.components.zeroconf.HaZeroconf"
+    ) as mock_zc, patch.object(hass.config_entries.flow, "async_init"), patch.object(
         zeroconf, "HaAsyncServiceBrowser", side_effect=service_update_mock
     ), patch(
         "homeassistant.components.zeroconf.network.async_get_adapters",
@@ -807,6 +809,33 @@ async def test_async_detect_interfaces_setting_empty_route(hass, mock_async_zero
     )
 
 
+async def test_async_detect_interfaces_setting_empty_route_freebsd(
+    hass, mock_async_zeroconf
+):
+    """Test without default interface config and the route returns nothing on freebsd."""
+    with patch("homeassistant.components.zeroconf.sys.platform", "freebsd"), patch(
+        "homeassistant.components.zeroconf.HaZeroconf"
+    ) as mock_zc, patch.object(hass.config_entries.flow, "async_init"), patch.object(
+        zeroconf, "HaAsyncServiceBrowser", side_effect=service_update_mock
+    ), patch(
+        "homeassistant.components.zeroconf.network.async_get_adapters",
+        return_value=_ADAPTERS_WITH_MANUAL_CONFIG,
+    ), patch(
+        "homeassistant.components.zeroconf.AsyncServiceInfo",
+        side_effect=get_service_info_mock,
+    ):
+        assert await async_setup_component(hass, zeroconf.DOMAIN, {zeroconf.DOMAIN: {}})
+        hass.bus.async_fire(EVENT_HOMEASSISTANT_STARTED)
+        await hass.async_block_till_done()
+    assert mock_zc.mock_calls[0] == call(
+        interfaces=[
+            "192.168.1.5",
+            "172.16.1.5",
+        ],
+        ip_version=IPVersion.V4Only,
+    )
+
+
 async def test_get_announced_addresses(hass, mock_async_zeroconf):
     """Test addresses for mDNS announcement."""
     expected = {
@@ -848,11 +877,13 @@ _ADAPTER_WITH_DEFAULT_ENABLED_AND_IPV6 = [
 ]
 
 
-async def test_async_detect_interfaces_explicitly_set_ipv6(hass, mock_async_zeroconf):
-    """Test interfaces are explicitly set when IPv6 is present."""
-    with patch("homeassistant.components.zeroconf.HaZeroconf") as mock_zc, patch.object(
-        hass.config_entries.flow, "async_init"
-    ), patch.object(
+async def test_async_detect_interfaces_explicitly_set_ipv6_linux(
+    hass, mock_async_zeroconf
+):
+    """Test interfaces are explicitly set when IPv6 is present on linux."""
+    with patch("homeassistant.components.zeroconf.sys.platform", "linux"), patch(
+        "homeassistant.components.zeroconf.HaZeroconf"
+    ) as mock_zc, patch.object(hass.config_entries.flow, "async_init"), patch.object(
         zeroconf, "HaAsyncServiceBrowser", side_effect=service_update_mock
     ), patch(
         "homeassistant.components.zeroconf.network.async_get_adapters",
@@ -871,6 +902,31 @@ async def test_async_detect_interfaces_explicitly_set_ipv6(hass, mock_async_zero
     )
 
 
+async def test_async_detect_interfaces_explicitly_set_ipv6_freebsd(
+    hass, mock_async_zeroconf
+):
+    """Test interfaces are explicitly set when IPv6 is present on freebsd."""
+    with patch("homeassistant.components.zeroconf.sys.platform", "freebsd"), patch(
+        "homeassistant.components.zeroconf.HaZeroconf"
+    ) as mock_zc, patch.object(hass.config_entries.flow, "async_init"), patch.object(
+        zeroconf, "HaAsyncServiceBrowser", side_effect=service_update_mock
+    ), patch(
+        "homeassistant.components.zeroconf.network.async_get_adapters",
+        return_value=_ADAPTER_WITH_DEFAULT_ENABLED_AND_IPV6,
+    ), patch(
+        "homeassistant.components.zeroconf.AsyncServiceInfo",
+        side_effect=get_service_info_mock,
+    ):
+        assert await async_setup_component(hass, zeroconf.DOMAIN, {zeroconf.DOMAIN: {}})
+        hass.bus.async_fire(EVENT_HOMEASSISTANT_STARTED)
+        await hass.async_block_till_done()
+
+    assert mock_zc.mock_calls[0] == call(
+        interfaces=InterfaceChoice.Default,
+        ip_version=IPVersion.V4Only,
+    )
+
+
 async def test_no_name(hass, mock_async_zeroconf):
     """Test fallback to Home for mDNS announcement if the name is missing."""
     hass.config.location_name = ""