diff --git a/homeassistant/helpers/config_entry_oauth2_flow.py b/homeassistant/helpers/config_entry_oauth2_flow.py
index d0aaca71304..2d45269a82c 100644
--- a/homeassistant/helpers/config_entry_oauth2_flow.py
+++ b/homeassistant/helpers/config_entry_oauth2_flow.py
@@ -25,6 +25,7 @@ from homeassistant import config_entries
 from homeassistant.components import http
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.data_entry_flow import FlowResult
+from homeassistant.loader import async_get_application_credentials
 
 from .aiohttp_client import async_get_clientsession
 from .network import NoURLAvailableError
@@ -239,6 +240,8 @@ class AbstractOAuth2FlowHandler(config_entries.ConfigFlow, metaclass=ABCMeta):
             return await self.async_step_auth()
 
         if not implementations:
+            if self.DOMAIN in await async_get_application_credentials(self.hass):
+                return self.async_abort(reason="missing_credentials")
             return self.async_abort(reason="missing_configuration")
 
         req = http.current_request.get()
diff --git a/homeassistant/strings.json b/homeassistant/strings.json
index 9dcf8c7fe49..e4d363c22be 100644
--- a/homeassistant/strings.json
+++ b/homeassistant/strings.json
@@ -71,6 +71,7 @@
         "webhook_not_internet_accessible": "Your Home Assistant instance needs to be accessible from the internet to receive webhook messages.",
         "oauth2_error": "Received invalid token data.",
         "oauth2_missing_configuration": "The component is not configured. Please follow the documentation.",
+        "oauth2_missing_credentials": "The integration requires application credentials.",
         "oauth2_authorize_url_timeout": "Timeout generating authorize URL.",
         "oauth2_no_url_available": "No URL available. For information about this error, [check the help section]({docs_url})",
         "reauth_successful": "Re-authentication was successful",
diff --git a/tests/components/google/test_config_flow.py b/tests/components/google/test_config_flow.py
index f061aeb3057..9339ca9988f 100644
--- a/tests/components/google/test_config_flow.py
+++ b/tests/components/google/test_config_flow.py
@@ -327,7 +327,7 @@ async def test_missing_configuration(
         DOMAIN, context={"source": config_entries.SOURCE_USER}
     )
     assert result.get("type") == "abort"
-    assert result.get("reason") == "missing_configuration"
+    assert result.get("reason") == "missing_credentials"
 
 
 @pytest.mark.parametrize("google_config", [None])
@@ -342,7 +342,7 @@ async def test_missing_configuration_yaml_empty(
         DOMAIN, context={"source": config_entries.SOURCE_USER}
     )
     assert result.get("type") == "abort"
-    assert result.get("reason") == "missing_configuration"
+    assert result.get("reason") == "missing_credentials"
 
 
 async def test_wrong_configuration(
diff --git a/tests/components/spotify/test_config_flow.py b/tests/components/spotify/test_config_flow.py
index e2f1878c04d..3b1e4851ff1 100644
--- a/tests/components/spotify/test_config_flow.py
+++ b/tests/components/spotify/test_config_flow.py
@@ -31,14 +31,14 @@ async def test_abort_if_no_configuration(hass):
     )
 
     assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
-    assert result["reason"] == "missing_configuration"
+    assert result["reason"] == "missing_credentials"
 
     result = await hass.config_entries.flow.async_init(
         DOMAIN, context={"source": SOURCE_ZEROCONF}, data=BLANK_ZEROCONF_INFO
     )
 
     assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
-    assert result["reason"] == "missing_configuration"
+    assert result["reason"] == "missing_credentials"
 
 
 async def test_zeroconf_abort_if_existing_entry(hass):
diff --git a/tests/components/yolink/test_config_flow.py b/tests/components/yolink/test_config_flow.py
index 4dd347f4076..5d6bb8fd727 100644
--- a/tests/components/yolink/test_config_flow.py
+++ b/tests/components/yolink/test_config_flow.py
@@ -25,7 +25,7 @@ async def test_abort_if_no_configuration(hass):
         DOMAIN, context={"source": config_entries.SOURCE_USER}
     )
     assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
-    assert result["reason"] == "missing_configuration"
+    assert result["reason"] == "missing_credentials"
 
 
 async def test_abort_if_existing_entry(hass: HomeAssistant):
diff --git a/tests/helpers/test_config_entry_oauth2_flow.py b/tests/helpers/test_config_entry_oauth2_flow.py
index 97e728d022d..248f3b8dbb0 100644
--- a/tests/helpers/test_config_entry_oauth2_flow.py
+++ b/tests/helpers/test_config_entry_oauth2_flow.py
@@ -114,6 +114,17 @@ async def test_abort_if_no_implementation(hass, flow_handler):
     assert result["reason"] == "missing_configuration"
 
 
+async def test_missing_credentials_for_domain(hass, flow_handler):
+    """Check flow abort for integration supporting application credentials."""
+    flow = flow_handler()
+    flow.hass = hass
+
+    with patch("homeassistant.loader.APPLICATION_CREDENTIALS", [TEST_DOMAIN]):
+        result = await flow.async_step_user()
+    assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
+    assert result["reason"] == "missing_credentials"
+
+
 async def test_abort_if_authorization_timeout(
     hass, flow_handler, local_impl, current_request_with_host
 ):