diff --git a/homeassistant/components/zha/config_flow.py b/homeassistant/components/zha/config_flow.py
index 1c7e0d105c4..f3f7f38772d 100644
--- a/homeassistant/components/zha/config_flow.py
+++ b/homeassistant/components/zha/config_flow.py
@@ -33,6 +33,7 @@ from homeassistant.config_entries import (
 from homeassistant.const import CONF_NAME
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.exceptions import HomeAssistantError
+from homeassistant.helpers.hassio import is_hassio
 from homeassistant.helpers.selector import FileSelector, FileSelectorConfig
 from homeassistant.util import dt as dt_util
 
@@ -104,25 +105,26 @@ async def list_serial_ports(hass: HomeAssistant) -> list[ListPortInfo]:
         yellow_radio.description = "Yellow Zigbee module"
         yellow_radio.manufacturer = "Nabu Casa"
 
-    # Present the multi-PAN addon as a setup option, if it's available
-    multipan_manager = await silabs_multiprotocol_addon.get_multiprotocol_addon_manager(
-        hass
-    )
-
-    try:
-        addon_info = await multipan_manager.async_get_addon_info()
-    except (AddonError, KeyError):
-        addon_info = None
-
-    if addon_info is not None and addon_info.state != AddonState.NOT_INSTALLED:
-        addon_port = ListPortInfo(
-            device=silabs_multiprotocol_addon.get_zigbee_socket(),
-            skip_link_detection=True,
+    if is_hassio(hass):
+        # Present the multi-PAN addon as a setup option, if it's available
+        multipan_manager = (
+            await silabs_multiprotocol_addon.get_multiprotocol_addon_manager(hass)
         )
 
-        addon_port.description = "Multiprotocol add-on"
-        addon_port.manufacturer = "Nabu Casa"
-        ports.append(addon_port)
+        try:
+            addon_info = await multipan_manager.async_get_addon_info()
+        except (AddonError, KeyError):
+            addon_info = None
+
+        if addon_info is not None and addon_info.state != AddonState.NOT_INSTALLED:
+            addon_port = ListPortInfo(
+                device=silabs_multiprotocol_addon.get_zigbee_socket(),
+                skip_link_detection=True,
+            )
+
+            addon_port.description = "Multiprotocol add-on"
+            addon_port.manufacturer = "Nabu Casa"
+            ports.append(addon_port)
 
     return ports
 
diff --git a/tests/components/zha/test_config_flow.py b/tests/components/zha/test_config_flow.py
index 1382c5c2569..87ba46a4ced 100644
--- a/tests/components/zha/test_config_flow.py
+++ b/tests/components/zha/test_config_flow.py
@@ -21,7 +21,7 @@ import zigpy.types
 
 from homeassistant import config_entries
 from homeassistant.components import ssdp, usb, zeroconf
-from homeassistant.components.hassio import AddonState
+from homeassistant.components.hassio import AddonError, AddonState
 from homeassistant.components.ssdp import ATTR_UPNP_MANUFACTURER_URL, ATTR_UPNP_SERIAL
 from homeassistant.components.zha import config_flow, radio_manager
 from homeassistant.components.zha.const import (
@@ -1878,10 +1878,23 @@ async def test_config_flow_port_yellow_port_name(hass: HomeAssistant) -> None:
     )
 
 
+async def test_config_flow_ports_no_hassio(hass: HomeAssistant) -> None:
+    """Test config flow serial port name when this is not a hassio install."""
+
+    with (
+        patch("homeassistant.components.zha.config_flow.is_hassio", return_value=False),
+        patch("serial.tools.list_ports.comports", MagicMock(return_value=[])),
+    ):
+        ports = await config_flow.list_serial_ports(hass)
+
+    assert ports == []
+
+
 async def test_config_flow_port_multiprotocol_port_name(hass: HomeAssistant) -> None:
     """Test config flow serial port name for multiprotocol add-on."""
 
     with (
+        patch("homeassistant.components.zha.config_flow.is_hassio", return_value=True),
         patch(
             "homeassistant.components.hassio.addon_manager.AddonManager.async_get_addon_info"
         ) as async_get_addon_info,
@@ -1889,16 +1902,28 @@ async def test_config_flow_port_multiprotocol_port_name(hass: HomeAssistant) ->
     ):
         async_get_addon_info.return_value.state = AddonState.RUNNING
         async_get_addon_info.return_value.hostname = "core-silabs-multiprotocol"
+        ports = await config_flow.list_serial_ports(hass)
 
-        result = await hass.config_entries.flow.async_init(
-            DOMAIN,
-            context={CONF_SOURCE: SOURCE_USER},
-        )
+    assert len(ports) == 1
+    assert ports[0].description == "Multiprotocol add-on"
+    assert ports[0].manufacturer == "Nabu Casa"
+    assert ports[0].device == "socket://core-silabs-multiprotocol:9999"
 
-    assert (
-        result["data_schema"].schema["path"].container[0]
-        == "socket://core-silabs-multiprotocol:9999 - Multiprotocol add-on - Nabu Casa"
-    )
+
+async def test_config_flow_port_no_multiprotocol(hass: HomeAssistant) -> None:
+    """Test config flow serial port listing when addon info fails to load."""
+
+    with (
+        patch("homeassistant.components.zha.config_flow.is_hassio", return_value=True),
+        patch(
+            "homeassistant.components.hassio.addon_manager.AddonManager.async_get_addon_info",
+            side_effect=AddonError,
+        ),
+        patch("serial.tools.list_ports.comports", MagicMock(return_value=[])),
+    ):
+        ports = await config_flow.list_serial_ports(hass)
+
+    assert ports == []
 
 
 @patch("serial.tools.list_ports.comports", MagicMock(return_value=[com_port()]))