diff --git a/homeassistant/components/myuplink/__init__.py b/homeassistant/components/myuplink/__init__.py
index 9d08144c77e..5910fe0cf6a 100644
--- a/homeassistant/components/myuplink/__init__.py
+++ b/homeassistant/components/myuplink/__init__.py
@@ -1,12 +1,15 @@
 """The myUplink integration."""
 from __future__ import annotations
 
+from http import HTTPStatus
+
+from aiohttp import ClientError, ClientResponseError
 from myuplink import MyUplinkAPI
 
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import Platform
 from homeassistant.core import HomeAssistant, callback
-from homeassistant.exceptions import ConfigEntryAuthFailed
+from homeassistant.exceptions import ConfigEntryAuthFailed, ConfigEntryNotReady
 from homeassistant.helpers import (
     aiohttp_client,
     config_entry_oauth2_flow,
@@ -34,12 +37,20 @@ async def async_setup_entry(hass: HomeAssistant, config_entry: ConfigEntry) -> b
         )
     )
     session = config_entry_oauth2_flow.OAuth2Session(hass, config_entry, implementation)
+    auth = AsyncConfigEntryAuth(aiohttp_client.async_get_clientsession(hass), session)
+
+    try:
+        await auth.async_get_access_token()
+    except ClientResponseError as err:
+        if err.status in {HTTPStatus.UNAUTHORIZED, HTTPStatus.FORBIDDEN}:
+            raise ConfigEntryAuthFailed from err
+        raise ConfigEntryNotReady from err
+    except ClientError as err:
+        raise ConfigEntryNotReady from err
 
     if set(config_entry.data["token"]["scope"].split(" ")) != set(OAUTH2_SCOPES):
         raise ConfigEntryAuthFailed("Incorrect OAuth2 scope")
 
-    auth = AsyncConfigEntryAuth(aiohttp_client.async_get_clientsession(hass), session)
-
     # Setup MyUplinkAPI and coordinator for data fetch
     api = MyUplinkAPI(auth)
     coordinator = MyUplinkDataCoordinator(hass, api)
diff --git a/tests/components/myuplink/test_init.py b/tests/components/myuplink/test_init.py
index 4134d2586df..728bcbc702f 100644
--- a/tests/components/myuplink/test_init.py
+++ b/tests/components/myuplink/test_init.py
@@ -38,7 +38,7 @@ async def test_load_unload_entry(
         (
             time.time() - 3600,
             http.HTTPStatus.UNAUTHORIZED,
-            ConfigEntryState.SETUP_RETRY,  # Will trigger reauth in the future
+            ConfigEntryState.SETUP_ERROR,
         ),
         (
             time.time() - 3600,