diff --git a/homeassistant/helpers/device_registry.py b/homeassistant/helpers/device_registry.py
index 4415babc009..bbe4131b758 100644
--- a/homeassistant/helpers/device_registry.py
+++ b/homeassistant/helpers/device_registry.py
@@ -13,6 +13,8 @@ from .debounce import Debouncer
 from .singleton import singleton
 from .typing import UNDEFINED, HomeAssistantType, UndefinedType
 
+# mypy: disallow_any_generics
+
 if TYPE_CHECKING:
     from . import entity_registry
 
@@ -124,7 +126,7 @@ class DeviceRegistry:
 
     devices: Dict[str, DeviceEntry]
     deleted_devices: Dict[str, DeletedDeviceEntry]
-    _devices_index: Dict[str, Dict[str, Dict[str, str]]]
+    _devices_index: Dict[str, Dict[str, Dict[Tuple[str, str], str]]]
 
     def __init__(self, hass: HomeAssistantType) -> None:
         """Initialize the device registry."""
@@ -140,8 +142,8 @@ class DeviceRegistry:
     @callback
     def async_get_device(
         self,
-        identifiers: set,
-        connections: Optional[set] = None,
+        identifiers: Set[Tuple[str, str]],
+        connections: Optional[Set[Tuple[str, str]]] = None,
     ) -> Optional[DeviceEntry]:
         """Check if device is registered."""
         device_id = self._async_get_device_id_from_index(
@@ -152,7 +154,9 @@ class DeviceRegistry:
         return self.devices[device_id]
 
     def _async_get_deleted_device(
-        self, identifiers: set, connections: Optional[set]
+        self,
+        identifiers: Set[Tuple[str, str]],
+        connections: Optional[Set[Tuple[str, str]]],
     ) -> Optional[DeletedDeviceEntry]:
         """Check if device is deleted."""
         device_id = self._async_get_device_id_from_index(
@@ -163,7 +167,10 @@ class DeviceRegistry:
         return self.deleted_devices[device_id]
 
     def _async_get_device_id_from_index(
-        self, index: str, identifiers: set, connections: Optional[set]
+        self,
+        index: str,
+        identifiers: Set[Tuple[str, str]],
+        connections: Optional[Set[Tuple[str, str]]],
     ) -> Optional[str]:
         """Check if device has previously been registered."""
         devices_index = self._devices_index[index]
@@ -227,8 +234,8 @@ class DeviceRegistry:
         self,
         *,
         config_entry_id: str,
-        connections: Optional[set] = None,
-        identifiers: Optional[set] = None,
+        connections: Optional[Set[Tuple[str, str]]] = None,
+        identifiers: Optional[Set[Tuple[str, str]]] = None,
         manufacturer: Union[str, None, UndefinedType] = UNDEFINED,
         model: Union[str, None, UndefinedType] = UNDEFINED,
         name: Union[str, None, UndefinedType] = UNDEFINED,
@@ -237,7 +244,7 @@ class DeviceRegistry:
         default_name: Union[str, None, UndefinedType] = UNDEFINED,
         sw_version: Union[str, None, UndefinedType] = UNDEFINED,
         entry_type: Union[str, None, UndefinedType] = UNDEFINED,
-        via_device: Optional[str] = None,
+        via_device: Optional[Tuple[str, str]] = None,
         # To disable a device if it gets created
         disabled_by: Union[str, None, UndefinedType] = UNDEFINED,
     ) -> Optional[DeviceEntry]:
@@ -305,7 +312,7 @@ class DeviceRegistry:
         model: Union[str, None, UndefinedType] = UNDEFINED,
         name: Union[str, None, UndefinedType] = UNDEFINED,
         name_by_user: Union[str, None, UndefinedType] = UNDEFINED,
-        new_identifiers: Union[set, UndefinedType] = UNDEFINED,
+        new_identifiers: Union[Set[Tuple[str, str]], UndefinedType] = UNDEFINED,
         sw_version: Union[str, None, UndefinedType] = UNDEFINED,
         via_device_id: Union[str, None, UndefinedType] = UNDEFINED,
         remove_config_entry_id: Union[str, UndefinedType] = UNDEFINED,
@@ -333,9 +340,9 @@ class DeviceRegistry:
         *,
         add_config_entry_id: Union[str, UndefinedType] = UNDEFINED,
         remove_config_entry_id: Union[str, UndefinedType] = UNDEFINED,
-        merge_connections: Union[set, UndefinedType] = UNDEFINED,
-        merge_identifiers: Union[set, UndefinedType] = UNDEFINED,
-        new_identifiers: Union[set, UndefinedType] = UNDEFINED,
+        merge_connections: Union[Set[Tuple[str, str]], UndefinedType] = UNDEFINED,
+        merge_identifiers: Union[Set[Tuple[str, str]], UndefinedType] = UNDEFINED,
+        new_identifiers: Union[Set[Tuple[str, str]], UndefinedType] = UNDEFINED,
         manufacturer: Union[str, None, UndefinedType] = UNDEFINED,
         model: Union[str, None, UndefinedType] = UNDEFINED,
         name: Union[str, None, UndefinedType] = UNDEFINED,
@@ -657,7 +664,7 @@ def async_setup_cleanup(hass: HomeAssistantType, dev_reg: DeviceRegistry) -> Non
     hass.bus.async_listen_once(EVENT_HOMEASSISTANT_STARTED, startup_clean)
 
 
-def _normalize_connections(connections: set) -> set:
+def _normalize_connections(connections: Set[Tuple[str, str]]) -> Set[Tuple[str, str]]:
     """Normalize connections to ensure we can match mac addresses."""
     return {
         (key, format_mac(value)) if key == CONNECTION_NETWORK_MAC else (key, value)
@@ -666,7 +673,8 @@ def _normalize_connections(connections: set) -> set:
 
 
 def _add_device_to_index(
-    devices_index: dict, device: Union[DeviceEntry, DeletedDeviceEntry]
+    devices_index: Dict[str, Dict[Tuple[str, str], str]],
+    device: Union[DeviceEntry, DeletedDeviceEntry],
 ) -> None:
     """Add a device to the index."""
     for identifier in device.identifiers:
@@ -676,7 +684,8 @@ def _add_device_to_index(
 
 
 def _remove_device_from_index(
-    devices_index: dict, device: Union[DeviceEntry, DeletedDeviceEntry]
+    devices_index: Dict[str, Dict[Tuple[str, str], str]],
+    device: Union[DeviceEntry, DeletedDeviceEntry],
 ) -> None:
     """Remove a device from the index."""
     for identifier in device.identifiers: