diff --git a/homeassistant/components/plugwise/config_flow.py b/homeassistant/components/plugwise/config_flow.py
index fbfdca00b41..3fee1445758 100644
--- a/homeassistant/components/plugwise/config_flow.py
+++ b/homeassistant/components/plugwise/config_flow.py
@@ -119,6 +119,32 @@ class PlugwiseConfigFlow(ConfigFlow, domain=DOMAIN):
         _version = _properties.get("version", "n/a")
         _name = f"{ZEROCONF_MAP.get(_product, _product)} v{_version}"
 
+        # This is an Anna, but we already have config entries.
+        # Assuming that the user has already configured Adam, aborting discovery.
+        if self._async_current_entries() and _product == "smile_thermo":
+            return self.async_abort(reason="anna_with_adam")
+
+        # If we have discovered an Adam or Anna, both might be on the network.
+        # In that case, we need to cancel the Anna flow, as the Adam should
+        # be added.
+        for flow in self._async_in_progress():
+            # This is an Anna, and there is already an Adam flow in progress
+            if (
+                _product == "smile_thermo"
+                and "context" in flow
+                and flow["context"].get("product") == "smile_open_therm"
+            ):
+                return self.async_abort(reason="anna_with_adam")
+
+            # This is an Adam, and there is already an Anna flow in progress
+            if (
+                _product == "smile_open_therm"
+                and "context" in flow
+                and flow["context"].get("product") == "smile_thermo"
+                and "flow_id" in flow
+            ):
+                self.hass.config_entries.flow.async_abort(flow["flow_id"])
+
         self.context.update(
             {
                 "title_placeholders": {
@@ -128,6 +154,7 @@ class PlugwiseConfigFlow(ConfigFlow, domain=DOMAIN):
                     CONF_USERNAME: self._username,
                 },
                 "configuration_url": f"http://{discovery_info.host}:{discovery_info.port}",
+                "product": _product,
             }
         )
         return await self.async_step_user()
diff --git a/homeassistant/components/plugwise/strings.json b/homeassistant/components/plugwise/strings.json
index 42dcee96196..7278f6c4414 100644
--- a/homeassistant/components/plugwise/strings.json
+++ b/homeassistant/components/plugwise/strings.json
@@ -19,7 +19,8 @@
       "unknown": "[%key:common::config_flow::error::unknown%]"
     },
     "abort": {
-      "already_configured": "[%key:common::config_flow::abort::already_configured_service%]"
+      "already_configured": "[%key:common::config_flow::abort::already_configured_service%]",
+      "anna_with_adam": "Both Anna and Adam detected. Add your Adam instead of your Anna"
     }
   }
 }
diff --git a/tests/components/plugwise/test_config_flow.py b/tests/components/plugwise/test_config_flow.py
index 66f0986682e..4dbe1d2615f 100644
--- a/tests/components/plugwise/test_config_flow.py
+++ b/tests/components/plugwise/test_config_flow.py
@@ -61,6 +61,34 @@ TEST_DISCOVERY2 = ZeroconfServiceInfo(
     type="mock_type",
 )
 
+TEST_DISCOVERY_ANNA = ZeroconfServiceInfo(
+    host=TEST_HOST,
+    addresses=[TEST_HOST],
+    hostname=f"{TEST_HOSTNAME}.local.",
+    name="mock_name",
+    port=DEFAULT_PORT,
+    properties={
+        "product": "smile_thermo",
+        "version": "1.2.3",
+        "hostname": f"{TEST_HOSTNAME}.local.",
+    },
+    type="mock_type",
+)
+
+TEST_DISCOVERY_ADAM = ZeroconfServiceInfo(
+    host=TEST_HOST,
+    addresses=[TEST_HOST],
+    hostname=f"{TEST_HOSTNAME2}.local.",
+    name="mock_name",
+    port=DEFAULT_PORT,
+    properties={
+        "product": "smile_open_therm",
+        "version": "1.2.3",
+        "hostname": f"{TEST_HOSTNAME2}.local.",
+    },
+    type="mock_type",
+)
+
 
 @pytest.fixture(name="mock_smile")
 def mock_smile():
@@ -294,3 +322,61 @@ async def test_flow_errors(
 
     assert len(mock_setup_entry.mock_calls) == 1
     assert len(mock_smile_config_flow.connect.mock_calls) == 2
+
+
+async def test_zeroconf_abort_anna_with_existing_config_entries(
+    hass: HomeAssistant,
+    mock_smile_adam: MagicMock,
+    init_integration: MockConfigEntry,
+) -> None:
+    """Test we abort Anna discovery with existing config entries."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_ZEROCONF},
+        data=TEST_DISCOVERY_ANNA,
+    )
+    assert result.get("type") == FlowResultType.ABORT
+    assert result.get("reason") == "anna_with_adam"
+
+
+async def test_zeroconf_abort_anna_with_adam(hass: HomeAssistant) -> None:
+    """Test we abort Anna discovery when an Adam is also discovered."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_ZEROCONF},
+        data=TEST_DISCOVERY_ANNA,
+    )
+    assert result.get("type") == FlowResultType.FORM
+    assert result.get("step_id") == "user"
+
+    flows_in_progress = hass.config_entries.flow.async_progress()
+    assert len(flows_in_progress) == 1
+    assert flows_in_progress[0]["context"]["product"] == "smile_thermo"
+
+    # Discover Adam, Anna should be aborted and no longer present
+    result2 = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_ZEROCONF},
+        data=TEST_DISCOVERY_ADAM,
+    )
+
+    assert result2.get("type") == FlowResultType.FORM
+    assert result2.get("step_id") == "user"
+
+    flows_in_progress = hass.config_entries.flow.async_progress()
+    assert len(flows_in_progress) == 1
+    assert flows_in_progress[0]["context"]["product"] == "smile_open_therm"
+
+    # Discover Anna again, Anna should be aborted directly
+    result3 = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={CONF_SOURCE: SOURCE_ZEROCONF},
+        data=TEST_DISCOVERY_ANNA,
+    )
+    assert result3.get("type") == FlowResultType.ABORT
+    assert result3.get("reason") == "anna_with_adam"
+
+    # Adam should still be there
+    flows_in_progress = hass.config_entries.flow.async_progress()
+    assert len(flows_in_progress) == 1
+    assert flows_in_progress[0]["context"]["product"] == "smile_open_therm"