diff --git a/homeassistant/helpers/device_registry.py b/homeassistant/helpers/device_registry.py
index aec5dbc6c4a..6b653784824 100644
--- a/homeassistant/helpers/device_registry.py
+++ b/homeassistant/helpers/device_registry.py
@@ -904,6 +904,7 @@ class DeviceRegistry(BaseRegistry[dict[str, list[dict[str, Any]]]]):
         if not new_values:
             return old
 
+        self.hass.verify_event_loop_thread("async_update_device")
         new = attr.evolve(old, **new_values)
         self.devices[device_id] = new
 
@@ -923,13 +924,14 @@ class DeviceRegistry(BaseRegistry[dict[str, list[dict[str, Any]]]]):
         else:
             data = {"action": "update", "device_id": new.id, "changes": old_values}
 
-        self.hass.bus.async_fire(EVENT_DEVICE_REGISTRY_UPDATED, data)
+        self.hass.bus.async_fire_internal(EVENT_DEVICE_REGISTRY_UPDATED, data)
 
         return new
 
     @callback
     def async_remove_device(self, device_id: str) -> None:
         """Remove a device from the device registry."""
+        self.hass.verify_event_loop_thread("async_remove_device")
         device = self.devices.pop(device_id)
         self.deleted_devices[device_id] = DeletedDeviceEntry(
             config_entries=device.config_entries,
@@ -941,7 +943,7 @@ class DeviceRegistry(BaseRegistry[dict[str, list[dict[str, Any]]]]):
         for other_device in list(self.devices.values()):
             if other_device.via_device_id == device_id:
                 self.async_update_device(other_device.id, via_device_id=None)
-        self.hass.bus.async_fire(
+        self.hass.bus.async_fire_internal(
             EVENT_DEVICE_REGISTRY_UPDATED,
             _EventDeviceRegistryUpdatedData_CreateRemove(
                 action="remove", device_id=device_id
diff --git a/tests/helpers/test_device_registry.py b/tests/helpers/test_device_registry.py
index ee895e3fd3e..6b167f8ee49 100644
--- a/tests/helpers/test_device_registry.py
+++ b/tests/helpers/test_device_registry.py
@@ -2,6 +2,7 @@
 
 from collections.abc import Iterable
 from contextlib import AbstractContextManager, nullcontext
+from functools import partial
 import time
 from typing import Any
 from unittest.mock import patch
@@ -2473,3 +2474,49 @@ async def test_device_name_translation_placeholders_errors(
         )
 
     assert expected_error in caplog.text
+
+
+async def test_async_get_or_create_thread_safety(
+    hass: HomeAssistant,
+    device_registry: dr.DeviceRegistry,
+    mock_config_entry: MockConfigEntry,
+) -> None:
+    """Test async_get_or_create raises when called from wrong thread."""
+
+    with pytest.raises(
+        RuntimeError,
+        match="Detected code that calls async_update_device from a thread. Please report this issue.",
+    ):
+        await hass.async_add_executor_job(
+            partial(
+                device_registry.async_get_or_create,
+                config_entry_id=mock_config_entry.entry_id,
+                connections={(dr.CONNECTION_NETWORK_MAC, "12:34:56:AB:CD:EF")},
+                identifiers=set(),
+                manufacturer="manufacturer",
+                model="model",
+            )
+        )
+
+
+async def test_async_remove_device_thread_safety(
+    hass: HomeAssistant,
+    device_registry: dr.DeviceRegistry,
+    mock_config_entry: MockConfigEntry,
+) -> None:
+    """Test async_remove_device raises when called from wrong thread."""
+    device = device_registry.async_get_or_create(
+        config_entry_id=mock_config_entry.entry_id,
+        connections={(dr.CONNECTION_NETWORK_MAC, "12:34:56:AB:CD:EF")},
+        identifiers=set(),
+        manufacturer="manufacturer",
+        model="model",
+    )
+
+    with pytest.raises(
+        RuntimeError,
+        match="Detected code that calls async_remove_device from a thread. Please report this issue.",
+    ):
+        await hass.async_add_executor_job(
+            device_registry.async_remove_device, device.id
+        )