diff --git a/CODEOWNERS b/CODEOWNERS
index c2be1901344..7e7f25ad153 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -1066,6 +1066,8 @@ homeassistant/components/updater/* @home-assistant/core
 tests/components/updater/* @home-assistant/core
 homeassistant/components/upnp/* @StevenLooman @ehendrix23
 tests/components/upnp/* @StevenLooman @ehendrix23
+homeassistant/components/uptime/* @frenck
+tests/components/uptime/* @frenck
 homeassistant/components/uptimerobot/* @ludeeus @chemelli74
 tests/components/uptimerobot/* @ludeeus @chemelli74
 homeassistant/components/usb/* @bdraco
diff --git a/homeassistant/components/uptime/__init__.py b/homeassistant/components/uptime/__init__.py
index 99abc91cdf1..1c36fea3b32 100644
--- a/homeassistant/components/uptime/__init__.py
+++ b/homeassistant/components/uptime/__init__.py
@@ -1 +1,16 @@
-"""The uptime component."""
+"""The Uptime integration."""
+from homeassistant.config_entries import ConfigEntry
+from homeassistant.core import HomeAssistant
+
+from .const import PLATFORMS
+
+
+async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+    """Set up from a config entry."""
+    hass.config_entries.async_setup_platforms(entry, PLATFORMS)
+    return True
+
+
+async def async_unload_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+    """Unload a config entry."""
+    return await hass.config_entries.async_unload_platforms(entry, PLATFORMS)
diff --git a/homeassistant/components/uptime/config_flow.py b/homeassistant/components/uptime/config_flow.py
new file mode 100644
index 00000000000..6ff36ee34b1
--- /dev/null
+++ b/homeassistant/components/uptime/config_flow.py
@@ -0,0 +1,37 @@
+"""Config flow to configure the Uptime integration."""
+from __future__ import annotations
+
+from typing import Any
+
+import voluptuous as vol
+
+from homeassistant.config_entries import ConfigFlow
+from homeassistant.const import CONF_NAME
+from homeassistant.data_entry_flow import FlowResult
+
+from .const import DEFAULT_NAME, DOMAIN
+
+
+class UptimeConfigFlow(ConfigFlow, domain=DOMAIN):
+    """Config flow for Uptime."""
+
+    VERSION = 1
+
+    async def async_step_user(
+        self, user_input: dict[str, Any] | None = None
+    ) -> FlowResult:
+        """Handle a flow initialized by the user."""
+        if self._async_current_entries():
+            return self.async_abort(reason="single_instance_allowed")
+
+        if user_input is not None:
+            return self.async_create_entry(
+                title=user_input.get(CONF_NAME, DEFAULT_NAME),
+                data={},
+            )
+
+        return self.async_show_form(step_id="user", data_schema=vol.Schema({}))
+
+    async def async_step_import(self, user_input: dict[str, Any]) -> FlowResult:
+        """Handle import from configuration.yaml."""
+        return await self.async_step_user(user_input)
diff --git a/homeassistant/components/uptime/const.py b/homeassistant/components/uptime/const.py
new file mode 100644
index 00000000000..bbce8021474
--- /dev/null
+++ b/homeassistant/components/uptime/const.py
@@ -0,0 +1,9 @@
+"""Constants for the Uptime integration."""
+from typing import Final
+
+from homeassistant.const import Platform
+
+DOMAIN: Final = "uptime"
+PLATFORMS: Final = [Platform.SENSOR]
+
+DEFAULT_NAME: Final = "Uptime"
diff --git a/homeassistant/components/uptime/manifest.json b/homeassistant/components/uptime/manifest.json
index cf2dd1a6ea1..3bcc47815f8 100644
--- a/homeassistant/components/uptime/manifest.json
+++ b/homeassistant/components/uptime/manifest.json
@@ -2,7 +2,8 @@
   "domain": "uptime",
   "name": "Uptime",
   "documentation": "https://www.home-assistant.io/integrations/uptime",
-  "codeowners": [],
+  "codeowners": ["@frenck"],
   "quality_scale": "internal",
-  "iot_class": "local_push"
+  "iot_class": "local_push",
+  "config_flow": true
 }
diff --git a/homeassistant/components/uptime/sensor.py b/homeassistant/components/uptime/sensor.py
index a622835a0da..944f9b77de8 100644
--- a/homeassistant/components/uptime/sensor.py
+++ b/homeassistant/components/uptime/sensor.py
@@ -8,6 +8,7 @@ from homeassistant.components.sensor import (
     SensorDeviceClass,
     SensorEntity,
 )
+from homeassistant.config_entries import SOURCE_IMPORT, ConfigEntry
 from homeassistant.const import CONF_NAME, CONF_UNIT_OF_MEASUREMENT
 from homeassistant.core import HomeAssistant
 import homeassistant.helpers.config_validation as cv
@@ -15,17 +16,15 @@ from homeassistant.helpers.entity_platform import AddEntitiesCallback
 from homeassistant.helpers.typing import ConfigType, DiscoveryInfoType
 import homeassistant.util.dt as dt_util
 
-DEFAULT_NAME = "Uptime"
+from .const import DEFAULT_NAME, DOMAIN
 
 PLATFORM_SCHEMA = vol.All(
-    cv.deprecated(CONF_UNIT_OF_MEASUREMENT),
+    cv.removed(CONF_UNIT_OF_MEASUREMENT, raise_if_present=False),
     PLATFORM_SCHEMA.extend(
         {
             vol.Optional(CONF_NAME, default=DEFAULT_NAME): cv.string,
-            vol.Optional(CONF_UNIT_OF_MEASUREMENT, default="days"): vol.All(
-                cv.string, vol.In(["minutes", "hours", "days", "seconds"])
-            ),
-        }
+            vol.Remove(CONF_UNIT_OF_MEASUREMENT): cv.string,
+        },
     ),
 )
 
@@ -37,9 +36,22 @@ async def async_setup_platform(
     discovery_info: DiscoveryInfoType | None = None,
 ) -> None:
     """Set up the uptime sensor platform."""
-    name = config[CONF_NAME]
+    hass.async_create_task(
+        hass.config_entries.flow.async_init(
+            DOMAIN,
+            context={"source": SOURCE_IMPORT},
+            data=config,
+        )
+    )
 
-    async_add_entities([UptimeSensor(name)], True)
+
+async def async_setup_entry(
+    hass: HomeAssistant,
+    entry: ConfigEntry,
+    async_add_entities: AddEntitiesCallback,
+) -> None:
+    """Set up the platform from config_entry."""
+    async_add_entities([UptimeSensor(entry)])
 
 
 class UptimeSensor(SensorEntity):
@@ -48,7 +60,8 @@ class UptimeSensor(SensorEntity):
     _attr_device_class = SensorDeviceClass.TIMESTAMP
     _attr_should_poll = False
 
-    def __init__(self, name: str) -> None:
+    def __init__(self, entry: ConfigEntry) -> None:
         """Initialize the uptime sensor."""
-        self._attr_name = name
+        self._attr_name = entry.title
         self._attr_native_value = dt_util.utcnow()
+        self._attr_unique_id = entry.entry_id
diff --git a/homeassistant/components/uptime/strings.json b/homeassistant/components/uptime/strings.json
new file mode 100644
index 00000000000..9ceb91de9ba
--- /dev/null
+++ b/homeassistant/components/uptime/strings.json
@@ -0,0 +1,13 @@
+{
+  "title": "Uptime",
+  "config": {
+    "step": {
+      "user": {
+        "description": "[%key:common::config_flow::description::confirm_setup%]"
+      }
+    },
+    "abort": {
+      "single_instance_allowed": "[%key:common::config_flow::abort::single_instance_allowed%]"
+    }
+  }
+}
diff --git a/homeassistant/components/uptime/translations/en.json b/homeassistant/components/uptime/translations/en.json
new file mode 100644
index 00000000000..5d38ae74e21
--- /dev/null
+++ b/homeassistant/components/uptime/translations/en.json
@@ -0,0 +1,13 @@
+{
+    "config": {
+        "abort": {
+            "single_instance_allowed": "Already configured. Only a single configuration possible."
+        },
+        "step": {
+            "user": {
+                "description": "Do you want to start set up?"
+            }
+        }
+    },
+    "title": "Uptime"
+}
\ No newline at end of file
diff --git a/homeassistant/generated/config_flows.py b/homeassistant/generated/config_flows.py
index 93592a2e1a9..b48df75c189 100644
--- a/homeassistant/generated/config_flows.py
+++ b/homeassistant/generated/config_flows.py
@@ -355,6 +355,7 @@ FLOWS = [
     "upb",
     "upcloud",
     "upnp",
+    "uptime",
     "uptimerobot",
     "vallox",
     "velbus",
diff --git a/tests/components/uptime/conftest.py b/tests/components/uptime/conftest.py
new file mode 100644
index 00000000000..7ee34856e63
--- /dev/null
+++ b/tests/components/uptime/conftest.py
@@ -0,0 +1,41 @@
+"""Fixtures for Uptime integration tests."""
+from __future__ import annotations
+
+from collections.abc import Generator
+from unittest.mock import patch
+
+import pytest
+
+from homeassistant.components.uptime.const import DOMAIN
+from homeassistant.core import HomeAssistant
+
+from tests.common import MockConfigEntry
+
+
+@pytest.fixture
+def mock_config_entry() -> MockConfigEntry:
+    """Return the default mocked config entry."""
+    return MockConfigEntry(
+        title="Uptime",
+        domain=DOMAIN,
+    )
+
+
+@pytest.fixture
+def mock_setup_entry() -> Generator[None, None, None]:
+    """Mock setting up a config entry."""
+    with patch("homeassistant.components.uptime.async_setup_entry", return_value=True):
+        yield
+
+
+@pytest.fixture
+async def init_integration(
+    hass: HomeAssistant, mock_config_entry: MockConfigEntry
+) -> MockConfigEntry:
+    """Set up the Uptime integration for testing."""
+    mock_config_entry.add_to_hass(hass)
+
+    await hass.config_entries.async_setup(mock_config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    return mock_config_entry
diff --git a/tests/components/uptime/test_config_flow.py b/tests/components/uptime/test_config_flow.py
new file mode 100644
index 00000000000..69ba00f6ac8
--- /dev/null
+++ b/tests/components/uptime/test_config_flow.py
@@ -0,0 +1,72 @@
+"""Tests for the Uptime config flow."""
+from unittest.mock import MagicMock
+
+import pytest
+
+from homeassistant.components.uptime.const import DOMAIN
+from homeassistant.config_entries import SOURCE_IMPORT, SOURCE_USER
+from homeassistant.const import CONF_NAME
+from homeassistant.core import HomeAssistant
+from homeassistant.data_entry_flow import (
+    RESULT_TYPE_ABORT,
+    RESULT_TYPE_CREATE_ENTRY,
+    RESULT_TYPE_FORM,
+)
+
+from tests.common import MockConfigEntry
+
+
+async def test_full_user_flow(
+    hass: HomeAssistant,
+    mock_setup_entry: MagicMock,
+) -> None:
+    """Test the full user configuration flow."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": SOURCE_USER}
+    )
+
+    assert result.get("type") == RESULT_TYPE_FORM
+    assert result.get("step_id") == SOURCE_USER
+    assert "flow_id" in result
+
+    result2 = await hass.config_entries.flow.async_configure(
+        result["flow_id"],
+        user_input={},
+    )
+
+    assert result2.get("type") == RESULT_TYPE_CREATE_ENTRY
+    assert result2.get("title") == "Uptime"
+    assert result2.get("data") == {}
+
+
+@pytest.mark.parametrize("source", [SOURCE_USER, SOURCE_IMPORT])
+async def test_single_instance_allowed(
+    hass: HomeAssistant,
+    mock_config_entry: MockConfigEntry,
+    source: str,
+) -> None:
+    """Test we abort if already setup."""
+    mock_config_entry.add_to_hass(hass)
+
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": source}
+    )
+
+    assert result.get("type") == RESULT_TYPE_ABORT
+    assert result.get("reason") == "single_instance_allowed"
+
+
+async def test_import_flow(
+    hass: HomeAssistant,
+    mock_setup_entry: MagicMock,
+) -> None:
+    """Test the import configuration flow."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={"source": SOURCE_IMPORT},
+        data={CONF_NAME: "My Uptime"},
+    )
+
+    assert result.get("type") == RESULT_TYPE_CREATE_ENTRY
+    assert result.get("title") == "My Uptime"
+    assert result.get("data") == {}
diff --git a/tests/components/uptime/test_init.py b/tests/components/uptime/test_init.py
new file mode 100644
index 00000000000..0f966734550
--- /dev/null
+++ b/tests/components/uptime/test_init.py
@@ -0,0 +1,55 @@
+"""Tests for the Uptime integration."""
+from unittest.mock import AsyncMock
+
+from homeassistant.components.sensor import DOMAIN as SENSOR_DOMAIN
+from homeassistant.components.uptime.const import DOMAIN
+from homeassistant.config_entries import ConfigEntryState
+from homeassistant.const import CONF_NAME
+from homeassistant.core import HomeAssistant
+from homeassistant.setup import async_setup_component
+
+from tests.common import MockConfigEntry
+
+
+async def test_load_unload_config_entry(
+    hass: HomeAssistant,
+    mock_config_entry: MockConfigEntry,
+) -> None:
+    """Test the Uptime configuration entry loading/unloading."""
+    mock_config_entry.add_to_hass(hass)
+    await hass.config_entries.async_setup(mock_config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    assert mock_config_entry.state is ConfigEntryState.LOADED
+
+    await hass.config_entries.async_unload(mock_config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    assert not hass.data.get(DOMAIN)
+    assert mock_config_entry.state is ConfigEntryState.NOT_LOADED
+
+
+async def test_import_config(
+    hass: HomeAssistant,
+    mock_setup_entry: AsyncMock,
+) -> None:
+    """Test Uptime being set up from config via import."""
+    assert await async_setup_component(
+        hass,
+        SENSOR_DOMAIN,
+        {
+            SENSOR_DOMAIN: {
+                "platform": DOMAIN,
+                CONF_NAME: "My Uptime",
+            }
+        },
+    )
+    await hass.async_block_till_done()
+
+    config_entries = hass.config_entries.async_entries(DOMAIN)
+    assert len(config_entries) == 1
+
+    entry = config_entries[0]
+    assert entry.title == "My Uptime"
+    assert entry.unique_id is None
+    assert entry.data == {}
diff --git a/tests/components/uptime/test_sensor.py b/tests/components/uptime/test_sensor.py
index fe3ae30a843..e8d0306246f 100644
--- a/tests/components/uptime/test_sensor.py
+++ b/tests/components/uptime/test_sensor.py
@@ -1,11 +1,27 @@
 """The tests for the uptime sensor platform."""
+import pytest
 
-from homeassistant.setup import async_setup_component
+from homeassistant.components.sensor import SensorDeviceClass
+from homeassistant.const import ATTR_DEVICE_CLASS
+from homeassistant.core import HomeAssistant
+from homeassistant.helpers import entity_registry as er
+
+from tests.common import MockConfigEntry
 
 
-async def test_uptime_sensor_name_change(hass):
-    """Test uptime sensor with different name."""
-    config = {"sensor": {"platform": "uptime", "name": "foobar"}}
-    assert await async_setup_component(hass, "sensor", config)
-    await hass.async_block_till_done()
-    assert hass.states.get("sensor.foobar")
+@pytest.mark.freeze_time("2022-03-01 00:00:00+00:00")
+async def test_uptime_sensor(
+    hass: HomeAssistant,
+    init_integration: MockConfigEntry,
+) -> None:
+    """Test Uptime sensor."""
+    state = hass.states.get("sensor.uptime")
+    assert state
+    assert state.state == "2022-03-01T00:00:00+00:00"
+    assert state.attributes["friendly_name"] == "Uptime"
+    assert state.attributes[ATTR_DEVICE_CLASS] == SensorDeviceClass.TIMESTAMP
+
+    entity_registry = er.async_get(hass)
+    entry = entity_registry.async_get("sensor.uptime")
+    assert entry
+    assert entry.unique_id == init_integration.entry_id